| Middlesex to Superior (Colorado) | 1,609.02 mi (2,589.46 km) |
| Middlesex to Superior (Wisconsin) | 972.68 mi (1,565.38 km) |
| Middlesex to Surprise (Arizona) | 2,126.84 mi (3,422.82 km) |
| Middlesex to Susanville (California) | 2,394.26 mi (3,853.19 km) |
| Middlesex to Sussex (Wisconsin) | 727.05 mi (1,170.08 km) |
| Middlesex to Suwanee (Georgia) | 691.76 mi (1,113.28 km) |
| Middlesex to Swansea (Illinois) | 835.44 mi (1,344.51 km) |
| Middlesex to Sweetwater (Florida) | 1,076.58 mi (1,732.59 km) |
| Middlesex to Sweetwater (Texas) | 1,536.65 mi (2,473.00 km) |
| Middlesex to Sycamore (Illinois) | 741.91 mi (1,193.99 km) |
| Middlesex to Sylacauga (Alabama) | 825.52 mi (1,328.54 km) |
| Middlesex to Sylvania (Ohio) | 485.26 mi (780.95 km) |
| Middlesex to Syosset (New York) | 54.93 mi (88.40 km) |
| Middlesex to Syracuse (New York) | 190.24 mi (306.16 km) |
| Middlesex to Syracuse (Utah) | 1,948.99 mi (3,136.60 km) |
