| Middlesex to Storm Lake (Iowa) | 1,075.88 mi (1,731.46 km) |
| Middlesex to Storrs (Connecticut) | 144.73 mi (232.93 km) |
| Middlesex to Stoughton (Wisconsin) | 774.95 mi (1,247.15 km) |
| Middlesex to Stow (Ohio) | 364.50 mi (586.61 km) |
| Middlesex to Streamwood (Illinois) | 716.16 mi (1,152.55 km) |
| Middlesex to Streator (Illinois) | 748.99 mi (1,205.39 km) |
| Middlesex to Streetsboro (Ohio) | 360.26 mi (579.78 km) |
| Middlesex to Strongsville (Ohio) | 385.83 mi (620.93 km) |
| Middlesex to Stuart (Florida) | 980.70 mi (1,578.29 km) |
| Middlesex to Stuarts Draft (Virginia) | 299.86 mi (482.58 km) |
| Middlesex to Sturgis (Michigan) | 573.54 mi (923.02 km) |
| Middlesex to Suamico (Wisconsin) | 743.68 mi (1,196.83 km) |
| Middlesex to Sudley (Virginia) | 201.48 mi (324.24 km) |
| Middlesex to Suffern (New York) | 41.72 mi (67.15 km) |
| Middlesex to Suffolk (Virginia) | 291.79 mi (469.60 km) |
