| Middlesex to Spout Springs (North Carolina) | 441.68 mi (710.81 km) |
| Middlesex to Spring (Texas) | 1,377.91 mi (2,217.54 km) |
| Middlesex to Spring Creek (Nevada) | 2,133.95 mi (3,434.25 km) |
| Middlesex to Spring Hill (Florida) | 951.42 mi (1,531.17 km) |
| Middlesex to Spring Hill (Tennessee) | 751.36 mi (1,209.20 km) |
| Middlesex to Spring Lake (North Carolina) | 445.71 mi (717.30 km) |
| Middlesex to Spring Valley (California) | 2,391.83 mi (3,849.28 km) |
| Middlesex to Spring Valley (Nevada) | 2,210.88 mi (3,558.07 km) |
| Middlesex to Spring Valley (New York) | 44.22 mi (71.16 km) |
| Middlesex to Springboro (Ohio) | 519.14 mi (835.47 km) |
| Middlesex to Springdale (Arkansas) | 1,104.20 mi (1,777.03 km) |
| Middlesex to Springdale (New Jersey) | 54.23 mi (87.27 km) |
| Middlesex to Springdale (Ohio) | 535.56 mi (861.90 km) |
| Middlesex to Springfield (Illinois) | 800.92 mi (1,288.96 km) |
| Middlesex to Springfield (Massachusetts) | 147.27 mi (237.01 km) |
