| Middlesex to Southern Pines (North Carolina) | 457.80 mi (736.76 km) |
| Middlesex to Southfield (Michigan) | 471.52 mi (758.84 km) |
| Middlesex to Southgate (Michigan) | 464.83 mi (748.07 km) |
| Middlesex to Southlake (Texas) | 1,354.71 mi (2,180.19 km) |
| Middlesex to Spanaway (Washington) | 2,391.83 mi (3,849.28 km) |
| Middlesex to Spanish Fork (Utah) | 1,941.42 mi (3,124.42 km) |
| Middlesex to Spanish Lake (Missouri) | 843.10 mi (1,356.84 km) |
| Middlesex to Spanish Springs (Nevada) | 2,360.88 mi (3,799.48 km) |
| Middlesex to Sparks (Nevada) | 2,364.90 mi (3,805.94 km) |
| Middlesex to Spartanburg (South Carolina) | 561.54 mi (903.71 km) |
| Middlesex to Spearfish (South Dakota) | 1,508.43 mi (2,427.58 km) |
| Middlesex to Speedway (Indiana) | 621.95 mi (1,000.93 km) |
| Middlesex to Spencer (Iowa) | 1,074.66 mi (1,729.49 km) |
| Middlesex to Spokane (Washington) | 2,155.86 mi (3,469.52 km) |
| Middlesex to Spokane Valley (Washington) | 2,146.66 mi (3,454.71 km) |
