| Middlesex to Somersworth (New Hampshire) | 262.28 mi (422.10 km) |
| Middlesex to Somerton (Arizona) | 2,276.23 mi (3,663.24 km) |
| Middlesex to Somerville (Massachusetts) | 216.11 mi (347.80 km) |
| Middlesex to Somerville (New Jersey) | 5.68 mi (9.15 km) |
| Middlesex to Sonoma (California) | 2,532.44 mi (4,075.57 km) |
| Middlesex to Soquel (California) | 2,536.44 mi (4,082.01 km) |
| Middlesex to South Bend (Indiana) | 616.73 mi (992.52 km) |
| Middlesex to South Bradenton (Florida) | 1,016.24 mi (1,635.48 km) |
| Middlesex to South Burlington (Vermont) | 276.42 mi (444.85 km) |
| Middlesex to South Charleston (West Virginia) | 414.44 mi (666.97 km) |
| Middlesex to South Daytona (Florida) | 869.58 mi (1,399.45 km) |
| Middlesex to South El Monte (California) | 2,410.11 mi (3,878.70 km) |
| Middlesex to South Elgin (Illinois) | 722.99 mi (1,163.54 km) |
| Middlesex to South Euclid (Ohio) | 371.69 mi (598.17 km) |
| Middlesex to South Farmingdale (New York) | 56.12 mi (90.32 km) |
