| Middlesex to Seymour (Tennessee) | 598.00 mi (962.38 km) |
| Middlesex to Shady Hills (Florida) | 956.55 mi (1,539.43 km) |
| Middlesex to Shafter (California) | 2,431.92 mi (3,913.80 km) |
| Middlesex to Shaker Heights (Ohio) | 372.53 mi (599.52 km) |
| Middlesex to Shakopee (Minnesota) | 1,004.01 mi (1,615.80 km) |
| Middlesex to Sharon (Pennsylvania) | 316.49 mi (509.34 km) |
| Middlesex to Sharonville (Ohio) | 532.10 mi (856.32 km) |
| Middlesex to Shasta Lake (California) | 2,478.50 mi (3,988.77 km) |
| Middlesex to Shawnee (Kansas) | 1,080.96 mi (1,739.64 km) |
| Middlesex to Shawnee (Oklahoma) | 1,271.71 mi (2,046.62 km) |
| Middlesex to Sheboygan (Wisconsin) | 711.15 mi (1,144.49 km) |
| Middlesex to Shelby (North Carolina) | 529.42 mi (852.02 km) |
| Middlesex to Shelbyville (Indiana) | 600.34 mi (966.16 km) |
| Middlesex to Shelbyville (Kentucky) | 595.32 mi (958.07 km) |
| Middlesex to Shelbyville (Tennessee) | 737.95 mi (1,187.61 km) |
