| Middlesex to Scottsboro (Alabama) | 752.29 mi (1,210.69 km) |
| Middlesex to Scottsdale (Arizona) | 2,095.91 mi (3,373.03 km) |
| Middlesex to Scranton (Pennsylvania) | 83.50 mi (134.38 km) |
| Middlesex to Seabrook (Maryland) | 166.40 mi (267.79 km) |
| Middlesex to Seabrook (Texas) | 1,381.73 mi (2,223.67 km) |
| Middlesex to Seaford (New York) | 53.30 mi (85.78 km) |
| Middlesex to Seagoville (Texas) | 1,334.65 mi (2,147.92 km) |
| Middlesex to Seal Beach (California) | 2,419.61 mi (3,893.98 km) |
| Middlesex to Searcy (Arkansas) | 1,007.02 mi (1,620.65 km) |
| Middlesex to Seaside (California) | 2,539.02 mi (4,086.16 km) |
| Middlesex to SeaTac (Washington) | 2,383.20 mi (3,835.38 km) |
| Middlesex to Seattle (Washington) | 2,383.04 mi (3,835.13 km) |
| Middlesex to Sebastian (Florida) | 947.04 mi (1,524.11 km) |
| Middlesex to Sebring (Florida) | 987.77 mi (1,589.67 km) |
| Middlesex to Secaucus (New Jersey) | 26.90 mi (43.30 km) |
