| Middlesex to Santa Rosa (California) | 2,541.58 mi (4,090.27 km) |
| Middlesex to Santaquin (Utah) | 1,951.55 mi (3,140.71 km) |
| Middlesex to Santee (California) | 2,388.61 mi (3,844.10 km) |
| Middlesex to Sapulpa (Oklahoma) | 1,209.58 mi (1,946.63 km) |
| Middlesex to Saraland (Alabama) | 1,014.50 mi (1,632.68 km) |
| Middlesex to Sarasota (Florida) | 1,022.93 mi (1,646.25 km) |
| Middlesex to Sarasota Springs (Florida) | 1,023.07 mi (1,646.48 km) |
| Middlesex to Saratoga (California) | 2,533.94 mi (4,077.98 km) |
| Middlesex to Saratoga Springs (New York) | 176.23 mi (283.62 km) |
| Middlesex to Saratoga Springs (Utah) | 1,951.90 mi (3,141.28 km) |
| Middlesex to Sartell (Minnesota) | 1,050.90 mi (1,691.25 km) |
| Middlesex to Satellite Beach (Florida) | 923.82 mi (1,486.75 km) |
| Middlesex to Sauk Rapids (Minnesota) | 1,047.44 mi (1,685.69 km) |
| Middlesex to Sault Ste. Marie (Michigan) | 640.34 mi (1,030.52 km) |
| Middlesex to Savage (Minnesota) | 998.26 mi (1,606.55 km) |
