| Middlesex to Sanford (Maine) | 275.13 mi (442.78 km) |
| Middlesex to Sanford (North Carolina) | 433.77 mi (698.09 km) |
| Middlesex to Sanger (California) | 2,419.90 mi (3,894.45 km) |
| Middlesex to Santa Ana (California) | 2,410.17 mi (3,878.79 km) |
| Middlesex to Santa Barbara (California) | 2,487.11 mi (4,002.61 km) |
| Middlesex to Santa Clara (California) | 2,528.63 mi (4,069.44 km) |
| Middlesex to Santa Clara (Oregon) | 2,459.32 mi (3,957.89 km) |
| Middlesex to Santa Clarita (California) | 2,423.40 mi (3,900.08 km) |
| Middlesex to Santa Cruz (California) | 2,541.36 mi (4,089.92 km) |
| Middlesex to Santa Fe (New Mexico) | 1,734.92 mi (2,792.09 km) |
| Middlesex to Santa Fe (Texas) | 1,393.41 mi (2,242.48 km) |
| Middlesex to Santa Fe Springs (California) | 2,414.11 mi (3,885.13 km) |
| Middlesex to Santa Maria (California) | 2,511.13 mi (4,041.27 km) |
| Middlesex to Santa Monica (California) | 2,433.49 mi (3,916.33 km) |
| Middlesex to Santa Paula (California) | 2,454.91 mi (3,950.80 km) |
