| Middlesex to San Luis Obispo (California) | 2,514.00 mi (4,045.90 km) |
| Middlesex to San Marcos (California) | 2,390.34 mi (3,846.88 km) |
| Middlesex to San Marcos (Texas) | 1,508.40 mi (2,427.54 km) |
| Middlesex to San Marino (California) | 2,411.47 mi (3,880.89 km) |
| Middlesex to San Mateo (California) | 2,541.91 mi (4,090.81 km) |
| Middlesex to San Pablo (California) | 2,533.90 mi (4,077.91 km) |
| Middlesex to San Rafael (California) | 2,542.48 mi (4,091.72 km) |
| Middlesex to San Ramon (California) | 2,517.66 mi (4,051.78 km) |
| Middlesex to San Tan Valley (Arizona) | 2,094.64 mi (3,370.99 km) |
| Middlesex to Sand Springs (Oklahoma) | 1,207.84 mi (1,943.84 km) |
| Middlesex to Sandusky (Ohio) | 431.65 mi (694.67 km) |
| Middlesex to Sandy (Oregon) | 2,401.39 mi (3,864.67 km) |
| Middlesex to Sandy (Utah) | 1,945.16 mi (3,130.44 km) |
| Middlesex to Sandy Springs (Georgia) | 709.75 mi (1,142.24 km) |
| Middlesex to Sanford (Florida) | 899.94 mi (1,448.31 km) |
