| Middlesex to Isabela (Puerto Rico) | 1,588.56 mi (2,556.54 km) |
| Middlesex to Iselin (New Jersey) | 9.66 mi (15.54 km) |
| Middlesex to Isla Vista (California) | 2,494.92 mi (4,015.19 km) |
| Middlesex to Issaquah (Washington) | 2,370.77 mi (3,815.38 km) |
| Middlesex to Ithaca (New York) | 165.58 mi (266.48 km) |
| Middlesex to Ives Estates (Florida) | 1,060.91 mi (1,707.37 km) |
| Middlesex to Jackson (Michigan) | 525.63 mi (845.91 km) |
| Middlesex to Jackson (Mississippi) | 1,040.67 mi (1,674.79 km) |
| Middlesex to Jackson (Missouri) | 842.02 mi (1,355.09 km) |
| Middlesex to Jackson (Tennessee) | 848.83 mi (1,366.07 km) |
| Middlesex to Jackson (Wyoming) | 1,857.75 mi (2,989.76 km) |
| Middlesex to Jacksonville (Alabama) | 774.92 mi (1,247.11 km) |
| Middlesex to Jacksonville (Arkansas) | 1,038.28 mi (1,670.94 km) |
| Middlesex to Jacksonville (Florida) | 814.03 mi (1,310.06 km) |
| Middlesex to Jacksonville (Illinois) | 831.68 mi (1,338.47 km) |
