| Middlesex to Enterprise (Nevada) | 2,211.11 mi (3,558.44 km) |
| Middlesex to Enumclaw (Washington) | 2,370.74 mi (3,815.34 km) |
| Middlesex to Ephrata (Pennsylvania) | 92.51 mi (148.88 km) |
| Middlesex to Erie (Colorado) | 1,601.39 mi (2,577.19 km) |
| Middlesex to Erie (Pennsylvania) | 307.98 mi (495.65 km) |
| Middlesex to Erlanger (Kentucky) | 545.88 mi (878.51 km) |
| Middlesex to Escanaba (Michigan) | 727.02 mi (1,170.03 km) |
| Middlesex to Escondido (California) | 2,385.00 mi (3,838.28 km) |
| Middlesex to Española (New Mexico) | 1,731.20 mi (2,786.09 km) |
| Middlesex to Essex (Maryland) | 135.39 mi (217.89 km) |
| Middlesex to Essex Junction (Vermont) | 279.61 mi (449.98 km) |
| Middlesex to Estelle (Louisiana) | 1,148.04 mi (1,847.59 km) |
| Middlesex to Estero (Florida) | 1,062.95 mi (1,710.65 km) |
| Middlesex to Euclid (Ohio) | 372.05 mi (598.76 km) |
| Middlesex to Eufaula (Alabama) | 841.68 mi (1,354.56 km) |
