| Middlesex to Elyria (Ohio) | 400.42 mi (644.42 km) |
| Middlesex to Emeryville (California) | 2,534.24 mi (4,078.47 km) |
| Middlesex to Emmaus (Pennsylvania) | 52.39 mi (84.32 km) |
| Middlesex to Emporia (Kansas) | 1,163.37 mi (1,872.27 km) |
| Middlesex to Encinitas (California) | 2,397.39 mi (3,858.23 km) |
| Middlesex to Endicott (New York) | 132.87 mi (213.83 km) |
| Middlesex to Endwell (New York) | 132.67 mi (213.52 km) |
| Middlesex to Englewood (Colorado) | 1,604.55 mi (2,582.27 km) |
| Middlesex to Englewood (Florida) | 1,041.31 mi (1,675.82 km) |
| Middlesex to Englewood (New Jersey) | 35.26 mi (56.75 km) |
| Middlesex to Englewood (Ohio) | 519.39 mi (835.88 km) |
| Middlesex to Enid (Oklahoma) | 1,292.06 mi (2,079.37 km) |
| Middlesex to Ennis (Texas) | 1,350.72 mi (2,173.77 km) |
| Middlesex to Ensley (Florida) | 996.72 mi (1,604.07 km) |
| Middlesex to Enterprise (Alabama) | 898.97 mi (1,446.76 km) |
