| Middlesbrough to Enumclaw (Washington) | 4,604.17 mi (7,409.69 km) |
| Middlesbrough to Ephrata (Pennsylvania) | 3,464.97 mi (5,576.33 km) |
| Middlesbrough to Erie (Colorado) | 4,509.64 mi (7,257.56 km) |
| Middlesbrough to Erie (Pennsylvania) | 3,521.65 mi (5,667.55 km) |
| Middlesbrough to Erlanger (Kentucky) | 3,840.96 mi (6,181.44 km) |
| Middlesbrough to Escanaba (Michigan) | 3,606.58 mi (5,804.23 km) |
| Middlesbrough to Escondido (California) | 5,283.77 mi (8,503.40 km) |
| Middlesbrough to Española (New Mexico) | 4,764.78 mi (7,668.17 km) |
| Middlesbrough to Essex (Maryland) | 3,516.93 mi (5,659.95 km) |
| Middlesbrough to Essex Junction (Vermont) | 3,150.61 mi (5,070.42 km) |
| Middlesbrough to Estelle (Louisiana) | 4,522.20 mi (7,277.79 km) |
| Middlesbrough to Estero (Florida) | 4,380.27 mi (7,049.36 km) |
| Middlesbrough to Euclid (Ohio) | 3,600.74 mi (5,794.84 km) |
| Middlesbrough to Eufaula (Alabama) | 4,223.33 mi (6,796.80 km) |
| Middlesbrough to Eugene (Oregon) | 4,817.04 mi (7,752.27 km) |
