| Middle Valley to Sesena | 4,309.93 mi (6,936.16 km) |
| Middle Valley to Sestao | 4,254.03 mi (6,846.21 km) |
| Middle Valley to Sevilla | 4,278.83 mi (6,886.12 km) |
| Middle Valley to Sevilla La Nueva | 4,287.14 mi (6,899.49 km) |
| Middle Valley to Silla | 4,489.84 mi (7,225.71 km) |
| Middle Valley to Silleda | 4,024.35 mi (6,476.56 km) |
| Middle Valley to Sitges | 4,537.34 mi (7,302.14 km) |
| Middle Valley to Socuellamos | 4,376.92 mi (7,043.97 km) |
| Middle Valley to Soller | 4,625.19 mi (7,443.53 km) |
| Middle Valley to Solsona | 4,500.88 mi (7,243.47 km) |
| Middle Valley to Son Servera | 4,660.96 mi (7,501.09 km) |
| Middle Valley to Sonseca | 4,309.19 mi (6,934.98 km) |
| Middle Valley to Sopelana | 4,253.35 mi (6,845.11 km) |
| Middle Valley to Soria | 4,321.71 mi (6,955.12 km) |
| Middle Valley to Suances | 4,202.37 mi (6,763.06 km) |
