| Middle River to Superior (Colorado) | 1,522.75 mi (2,450.63 km) |
| Middle River to Superior (Wisconsin) | 937.33 mi (1,508.49 km) |
| Middle River to Surprise (Arizona) | 2,024.64 mi (3,258.35 km) |
| Middle River to Susanville (California) | 2,319.27 mi (3,732.50 km) |
| Middle River to Sussex (Wisconsin) | 665.79 mi (1,071.48 km) |
| Middle River to Suwanee (Georgia) | 559.10 mi (899.79 km) |
| Middle River to Swansea (Illinois) | 730.05 mi (1,174.90 km) |
| Middle River to Sweetwater (Florida) | 964.79 mi (1,552.68 km) |
| Middle River to Sweetwater (Texas) | 1,418.62 mi (2,283.05 km) |
| Middle River to Sycamore (Illinois) | 667.28 mi (1,073.88 km) |
| Middle River to Sylacauga (Alabama) | 693.33 mi (1,115.80 km) |
| Middle River to Sylvania (Ohio) | 415.83 mi (669.22 km) |
| Middle River to Syosset (New York) | 185.00 mi (297.72 km) |
| Middle River to Syracuse (New York) | 255.86 mi (411.77 km) |
| Middle River to Syracuse (Utah) | 1,871.40 mi (3,011.74 km) |
