| Middle River to Storm Lake (Iowa) | 1,002.82 mi (1,613.89 km) |
| Middle River to Storrs (Connecticut) | 277.39 mi (446.42 km) |
| Middle River to Stoughton (Wisconsin) | 709.52 mi (1,141.86 km) |
| Middle River to Stow (Ohio) | 292.84 mi (471.28 km) |
| Middle River to Streamwood (Illinois) | 642.36 mi (1,033.78 km) |
| Middle River to Streator (Illinois) | 665.15 mi (1,070.46 km) |
| Middle River to Streetsboro (Ohio) | 290.46 mi (467.45 km) |
| Middle River to Strongsville (Ohio) | 315.51 mi (507.76 km) |
| Middle River to Stuart (Florida) | 867.59 mi (1,396.26 km) |
| Middle River to Stuarts Draft (Virginia) | 167.91 mi (270.22 km) |
| Middle River to Sturgis (Michigan) | 501.25 mi (806.68 km) |
| Middle River to Suamico (Wisconsin) | 699.84 mi (1,126.28 km) |
| Middle River to Sudley (Virginia) | 69.10 mi (111.20 km) |
| Middle River to Suffern (New York) | 171.64 mi (276.23 km) |
| Middle River to Suffolk (Virginia) | 183.35 mi (295.08 km) |
