| Middle River to Southern Pines (North Carolina) | 330.22 mi (531.43 km) |
| Middle River to Southfield (Michigan) | 417.22 mi (671.45 km) |
| Middle River to Southgate (Michigan) | 405.95 mi (653.32 km) |
| Middle River to Southlake (Texas) | 1,234.16 mi (1,986.19 km) |
| Middle River to Spanaway (Washington) | 2,341.51 mi (3,768.30 km) |
| Middle River to Spanish Fork (Utah) | 1,859.75 mi (2,992.99 km) |
| Middle River to Spanish Lake (Missouri) | 739.64 mi (1,190.34 km) |
| Middle River to Spanish Springs (Nevada) | 2,282.76 mi (3,673.75 km) |
| Middle River to Sparks (Nevada) | 2,286.54 mi (3,679.83 km) |
| Middle River to Spartanburg (South Carolina) | 428.95 mi (690.33 km) |
| Middle River to Spearfish (South Dakota) | 1,444.98 mi (2,325.48 km) |
| Middle River to Speedway (Indiana) | 523.84 mi (843.03 km) |
| Middle River to Spencer (Iowa) | 1,005.40 mi (1,618.04 km) |
| Middle River to Spokane (Washington) | 2,107.02 mi (3,390.92 km) |
| Middle River to Spokane Valley (Washington) | 2,097.78 mi (3,376.05 km) |
