| Middle River to Santa Rosa (California) | 2,461.84 mi (3,961.94 km) |
| Middle River to Santaquin (Utah) | 1,869.44 mi (3,008.57 km) |
| Middle River to Santee (California) | 2,288.56 mi (3,683.09 km) |
| Middle River to Sapulpa (Oklahoma) | 1,097.97 mi (1,767.01 km) |
| Middle River to Saraland (Alabama) | 881.87 mi (1,419.23 km) |
| Middle River to Sarasota (Florida) | 900.90 mi (1,449.86 km) |
| Middle River to Sarasota Springs (Florida) | 901.30 mi (1,450.50 km) |
| Middle River to Saratoga (California) | 2,450.22 mi (3,943.24 km) |
| Middle River to Saratoga Springs (New York) | 291.75 mi (469.53 km) |
| Middle River to Saratoga Springs (Utah) | 1,871.31 mi (3,011.58 km) |
| Middle River to Sartell (Minnesota) | 1,002.16 mi (1,612.82 km) |
| Middle River to Satellite Beach (Florida) | 807.63 mi (1,299.75 km) |
| Middle River to Sauk Rapids (Minnesota) | 998.64 mi (1,607.15 km) |
| Middle River to Sault Ste. Marie (Michigan) | 635.68 mi (1,023.03 km) |
| Middle River to Savage (Minnesota) | 943.70 mi (1,518.74 km) |
