| Middle River to Enterprise (Nevada) | 2,118.11 mi (3,408.76 km) |
| Middle River to Enumclaw (Washington) | 2,320.72 mi (3,734.83 km) |
| Middle River to Ephrata (Pennsylvania) | 59.30 mi (95.43 km) |
| Middle River to Erie (Colorado) | 1,515.54 mi (2,439.02 km) |
| Middle River to Erie (Pennsylvania) | 270.49 mi (435.31 km) |
| Middle River to Erlanger (Kentucky) | 437.57 mi (704.20 km) |
| Middle River to Escanaba (Michigan) | 699.30 mi (1,125.42 km) |
| Middle River to Escondido (California) | 2,285.73 mi (3,678.52 km) |
| Middle River to Española (New Mexico) | 1,630.02 mi (2,623.27 km) |
| Middle River to Essex (Maryland) | 3.05 mi (4.91 km) |
| Middle River to Essex Junction (Vermont) | 394.16 mi (634.33 km) |
| Middle River to Estelle (Louisiana) | 1,015.66 mi (1,634.55 km) |
| Middle River to Estero (Florida) | 944.73 mi (1,520.40 km) |
| Middle River to Euclid (Ohio) | 309.41 mi (497.94 km) |
| Middle River to Eufaula (Alabama) | 709.14 mi (1,141.26 km) |
