| Middle River to Entroncamento | 3,535.43 mi (5,689.72 km) |
| Middle River to Ericeira | 3,502.25 mi (5,636.33 km) |
| Middle River to Ermezinde | 3,485.38 mi (5,609.17 km) |
| Middle River to Esmoriz | 3,488.37 mi (5,613.98 km) |
| Middle River to Espinho | 3,486.32 mi (5,610.70 km) |
| Middle River to Esposende | 3,466.11 mi (5,578.16 km) |
| Middle River to Estarreja | 3,496.58 mi (5,627.21 km) |
| Middle River to Estoril | 3,510.23 mi (5,649.17 km) |
| Middle River to Estremoz | 3,595.83 mi (5,786.93 km) |
| Middle River to Evora | 3,588.14 mi (5,774.56 km) |
| Middle River to Fafe | 3,497.91 mi (5,629.33 km) |
| Middle River to Falagueira | 3,517.27 mi (5,660.49 km) |
| Middle River to Famalicao | 3,481.90 mi (5,603.57 km) |
| Middle River to Fanzeres | 3,487.47 mi (5,612.54 km) |
| Middle River to Faro | 3,630.76 mi (5,843.15 km) |
