| Middle River to Spello | 4,409.56 mi (7,096.50 km) |
| Middle River to Spilamberto | 4,284.90 mi (6,895.89 km) |
| Middle River to Spilimbergo | 4,310.62 mi (6,937.28 km) |
| Middle River to Spinea | 4,301.55 mi (6,922.68 km) |
| Middle River to Spoleto | 4,418.30 mi (7,110.57 km) |
| Middle River to Spoltore | 4,492.42 mi (7,229.85 km) |
| Middle River to Spresiano | 4,295.58 mi (6,913.07 km) |
| Middle River to Squinzano | 4,738.27 mi (7,625.51 km) |
| Middle River to Statte | 4,696.05 mi (7,557.56 km) |
| Middle River to Stezzano | 4,189.70 mi (6,742.66 km) |
| Middle River to Strada | 4,329.99 mi (6,968.44 km) |
| Middle River to Stradella | 4,192.81 mi (6,747.67 km) |
| Middle River to Striano | 4,570.90 mi (7,356.16 km) |
| Middle River to Subiaco | 4,465.66 mi (7,186.78 km) |
| Middle River to Sulmona | 4,497.78 mi (7,238.48 km) |
