| Middle River to Sestu | 4,378.05 mi (7,045.79 km) |
| Middle River to Settimo Torinese | 4,124.84 mi (6,638.28 km) |
| Middle River to Seveso | 4,167.87 mi (6,707.53 km) |
| Middle River to Sezze | 4,479.71 mi (7,209.39 km) |
| Middle River to Siano | 4,577.07 mi (7,366.08 km) |
| Middle River to Siena | 4,339.68 mi (6,984.03 km) |
| Middle River to Signa | 4,313.76 mi (6,942.33 km) |
| Middle River to Silea | 4,301.87 mi (6,923.19 km) |
| Middle River to Silvi Paese | 4,487.99 mi (7,222.72 km) |
| Middle River to Sinalunga | 4,360.71 mi (7,017.88 km) |
| Middle River to Siniscola | 4,361.33 mi (7,018.88 km) |
| Middle River to Sinnai | 4,383.07 mi (7,053.87 km) |
| Middle River to Siracusa | 4,744.80 mi (7,636.02 km) |
| Middle River to Solaro | 4,166.48 mi (6,705.30 km) |
| Middle River to Soliera | 4,274.10 mi (6,878.49 km) |
