| Middle Island to Southern Pines (North Carolina) | 527.17 mi (848.39 km) |
| Middle Island to Southfield (Michigan) | 543.15 mi (874.12 km) |
| Middle Island to Southgate (Michigan) | 538.00 mi (865.83 km) |
| Middle Island to Southlake (Texas) | 1,438.95 mi (2,315.76 km) |
| Middle Island to Spanaway (Washington) | 2,454.52 mi (3,950.17 km) |
| Middle Island to Spanish Fork (Utah) | 2,017.03 mi (3,246.10 km) |
| Middle Island to Spanish Lake (Missouri) | 925.67 mi (1,489.72 km) |
| Middle Island to Spanish Springs (Nevada) | 2,434.96 mi (3,918.70 km) |
| Middle Island to Sparks (Nevada) | 2,439.07 mi (3,925.30 km) |
| Middle Island to Spartanburg (South Carolina) | 638.22 mi (1,027.11 km) |
| Middle Island to Spearfish (South Dakota) | 1,577.83 mi (2,539.27 km) |
| Middle Island to Speedway (Indiana) | 703.94 mi (1,132.88 km) |
| Middle Island to Spencer (Iowa) | 1,147.22 mi (1,846.27 km) |
| Middle Island to Spokane (Washington) | 2,218.14 mi (3,569.76 km) |
| Middle Island to Spokane Valley (Washington) | 2,208.97 mi (3,554.99 km) |
