| Middle Island to Enterprise (Nevada) | 2,290.20 mi (3,685.72 km) |
| Middle Island to Enumclaw (Washington) | 2,433.32 mi (3,916.06 km) |
| Middle Island to Ephrata (Pennsylvania) | 176.74 mi (284.44 km) |
| Middle Island to Erie (Colorado) | 1,678.66 mi (2,701.55 km) |
| Middle Island to Erie (Pennsylvania) | 378.40 mi (608.98 km) |
| Middle Island to Erlanger (Kentucky) | 629.55 mi (1,013.17 km) |
| Middle Island to Escanaba (Michigan) | 784.94 mi (1,263.23 km) |
| Middle Island to Escondido (California) | 2,465.78 mi (3,968.29 km) |
| Middle Island to Española (New Mexico) | 1,812.67 mi (2,917.22 km) |
| Middle Island to Essex (Maryland) | 214.88 mi (345.82 km) |
| Middle Island to Essex Junction (Vermont) | 249.19 mi (401.04 km) |
| Middle Island to Estelle (Louisiana) | 1,227.51 mi (1,975.49 km) |
| Middle Island to Estero (Florida) | 1,119.64 mi (1,801.88 km) |
| Middle Island to Euclid (Ohio) | 447.91 mi (720.84 km) |
| Middle Island to Eufaula (Alabama) | 917.73 mi (1,476.94 km) |
