| Middle Island to Elyria (Ohio) | 477.71 mi (768.80 km) |
| Middle Island to Emeryville (California) | 2,609.57 mi (4,199.69 km) |
| Middle Island to Emmaus (Pennsylvania) | 135.85 mi (218.63 km) |
| Middle Island to Emporia (Kansas) | 1,244.95 mi (2,003.56 km) |
| Middle Island to Encinitas (California) | 2,478.19 mi (3,988.26 km) |
| Middle Island to Endicott (New York) | 181.82 mi (292.61 km) |
| Middle Island to Endwell (New York) | 180.53 mi (290.54 km) |
| Middle Island to Englewood (Colorado) | 1,682.38 mi (2,707.53 km) |
| Middle Island to Englewood (Florida) | 1,100.67 mi (1,771.36 km) |
| Middle Island to Englewood (New Jersey) | 53.71 mi (86.43 km) |
| Middle Island to Englewood (Ohio) | 601.75 mi (968.43 km) |
| Middle Island to Enid (Oklahoma) | 1,375.11 mi (2,213.02 km) |
| Middle Island to Ennis (Texas) | 1,434.88 mi (2,309.21 km) |
| Middle Island to Ensley (Florida) | 1,073.74 mi (1,728.02 km) |
| Middle Island to Enterprise (Alabama) | 975.12 mi (1,569.31 km) |
