| Middle Island to Sestu | 4,165.58 mi (6,703.86 km) |
| Middle Island to Settimo Torinese | 3,913.00 mi (6,297.36 km) |
| Middle Island to Seveso | 3,956.37 mi (6,367.16 km) |
| Middle Island to Sezze | 4,267.51 mi (6,867.89 km) |
| Middle Island to Siano | 4,364.88 mi (7,024.60 km) |
| Middle Island to Siena | 4,127.71 mi (6,642.91 km) |
| Middle Island to Signa | 4,101.90 mi (6,601.37 km) |
| Middle Island to Silea | 4,090.85 mi (6,583.59 km) |
| Middle Island to Silvi Paese | 4,276.14 mi (6,881.78 km) |
| Middle Island to Sinalunga | 4,148.76 mi (6,676.79 km) |
| Middle Island to Siniscola | 4,148.85 mi (6,676.93 km) |
| Middle Island to Sinnai | 4,170.60 mi (6,711.93 km) |
| Middle Island to Siracusa | 4,532.31 mi (7,294.05 km) |
| Middle Island to Solaro | 3,954.96 mi (6,364.89 km) |
| Middle Island to Soliera | 4,062.51 mi (6,537.98 km) |
