| Michigan City to Southern Pines (North Carolina) | 604.39 mi (972.67 km) |
| Michigan City to Southfield (Michigan) | 192.44 mi (309.70 km) |
| Michigan City to Southgate (Michigan) | 191.30 mi (307.86 km) |
| Michigan City to Southlake (Texas) | 826.39 mi (1,329.94 km) |
| Michigan City to Spanaway (Washington) | 1,777.91 mi (2,861.27 km) |
| Michigan City to Spanish Fork (Utah) | 1,293.72 mi (2,082.03 km) |
| Michigan City to Spanish Lake (Missouri) | 267.77 mi (430.94 km) |
| Michigan City to Spanish Springs (Nevada) | 1,714.02 mi (2,758.45 km) |
| Michigan City to Sparks (Nevada) | 1,717.96 mi (2,764.79 km) |
| Michigan City to Spartanburg (South Carolina) | 538.54 mi (866.70 km) |
| Michigan City to Spearfish (South Dakota) | 874.55 mi (1,407.46 km) |
| Michigan City to Speedway (Indiana) | 136.28 mi (219.32 km) |
| Michigan City to Spencer (Iowa) | 433.82 mi (698.16 km) |
| Michigan City to Spokane (Washington) | 1,545.59 mi (2,487.38 km) |
| Michigan City to Spokane Valley (Washington) | 1,536.36 mi (2,472.53 km) |
