| Michigan City to Santa Rosa (California) | 1,894.27 mi (3,048.53 km) |
| Michigan City to Santaquin (Utah) | 1,303.82 mi (2,098.30 km) |
| Michigan City to Santee (California) | 1,754.10 mi (2,822.95 km) |
| Michigan City to Sapulpa (Oklahoma) | 633.23 mi (1,019.08 km) |
| Michigan City to Saraland (Alabama) | 753.55 mi (1,212.72 km) |
| Michigan City to Sarasota (Florida) | 1,022.60 mi (1,645.72 km) |
| Michigan City to Sarasota Springs (Florida) | 1,025.56 mi (1,650.48 km) |
| Michigan City to Saratoga (California) | 1,886.23 mi (3,035.59 km) |
| Michigan City to Saratoga Springs (New York) | 673.93 mi (1,084.59 km) |
| Michigan City to Saratoga Springs (Utah) | 1,304.30 mi (2,099.07 km) |
| Michigan City to Sartell (Minnesota) | 455.74 mi (733.45 km) |
| Michigan City to Satellite Beach (Florida) | 999.27 mi (1,608.17 km) |
| Michigan City to Sauk Rapids (Minnesota) | 452.27 mi (727.85 km) |
| Michigan City to Sault Ste. Marie (Michigan) | 352.20 mi (566.82 km) |
| Michigan City to Savage (Minnesota) | 388.59 mi (625.38 km) |
