| Michigan City to Enterprise (Nevada) | 1,567.96 mi (2,523.38 km) |
| Michigan City to Enumclaw (Washington) | 1,757.44 mi (2,828.33 km) |
| Michigan City to Ephrata (Pennsylvania) | 567.29 mi (912.97 km) |
| Michigan City to Erie (Colorado) | 954.49 mi (1,536.11 km) |
| Michigan City to Erie (Pennsylvania) | 350.45 mi (563.99 km) |
| Michigan City to Erlanger (Kentucky) | 221.79 mi (356.94 km) |
| Michigan City to Escanaba (Michigan) | 279.25 mi (449.41 km) |
| Michigan City to Escondido (California) | 1,749.21 mi (2,815.08 km) |
| Michigan City to Española (New Mexico) | 1,102.70 mi (1,774.62 km) |
| Michigan City to Essex (Maryland) | 571.89 mi (920.38 km) |
| Michigan City to Essex Junction (Vermont) | 719.05 mi (1,157.20 km) |
| Michigan City to Estelle (Louisiana) | 839.37 mi (1,350.84 km) |
| Michigan City to Estero (Florida) | 1,094.51 mi (1,761.45 km) |
| Michigan City to Euclid (Ohio) | 276.30 mi (444.66 km) |
| Michigan City to Eufaula (Alabama) | 683.64 mi (1,100.22 km) |
