| Mendrisio to Southern Pines (North Carolina) | 4,460.25 mi (7,178.08 km) |
| Mendrisio to Southfield (Michigan) | 4,305.77 mi (6,929.47 km) |
| Mendrisio to Southgate (Michigan) | 4,315.20 mi (6,944.64 km) |
| Mendrisio to Southlake (Texas) | 5,307.55 mi (8,541.68 km) |
| Mendrisio to Spanaway (Washington) | 5,371.81 mi (8,645.10 km) |
| Mendrisio to Spanish Fork (Utah) | 5,457.14 mi (8,782.42 km) |
| Mendrisio to Spanish Lake (Missouri) | 4,748.12 mi (7,641.35 km) |
| Mendrisio to Spanish Springs (Nevada) | 5,729.44 mi (9,220.64 km) |
| Mendrisio to Sparks (Nevada) | 5,735.61 mi (9,230.57 km) |
| Mendrisio to Spartanburg (South Carolina) | 4,580.46 mi (7,371.54 km) |
| Mendrisio to Spearfish (South Dakota) | 4,968.57 mi (7,996.14 km) |
| Mendrisio to Speedway (Indiana) | 4,543.50 mi (7,312.06 km) |
| Mendrisio to Spencer (Iowa) | 4,731.85 mi (7,615.18 km) |
| Mendrisio to Spokane (Washington) | 5,209.14 mi (8,383.30 km) |
| Mendrisio to Spokane Valley (Washington) | 5,204.04 mi (8,375.10 km) |
