| McDonough to Southern Pines (North Carolina) | 296.67 mi (477.45 km) |
| McDonough to Southfield (Michigan) | 626.25 mi (1,007.85 km) |
| McDonough to Southgate (Michigan) | 607.78 mi (978.13 km) |
| McDonough to Southlake (Texas) | 751.86 mi (1,210.01 km) |
| McDonough to Spanaway (Washington) | 2,199.15 mi (3,539.19 km) |
| McDonough to Spanish Fork (Utah) | 1,582.37 mi (2,546.59 km) |
| McDonough to Spanish Lake (Missouri) | 500.63 mi (805.68 km) |
| McDonough to Spanish Springs (Nevada) | 2,004.06 mi (3,225.23 km) |
| McDonough to Sparks (Nevada) | 2,006.45 mi (3,229.07 km) |
| McDonough to Spartanburg (South Carolina) | 164.25 mi (264.34 km) |
| McDonough to Spearfish (South Dakota) | 1,297.87 mi (2,088.72 km) |
| McDonough to Speedway (Indiana) | 454.13 mi (730.85 km) |
| McDonough to Spencer (Iowa) | 896.09 mi (1,442.11 km) |
| McDonough to Spokane (Washington) | 1,982.93 mi (3,191.21 km) |
| McDonough to Spokane Valley (Washington) | 1,974.03 mi (3,176.90 km) |
