| McDonough to Olympia Heights (Florida) | 580.08 mi (933.55 km) |
| McDonough to Omaha (Nebraska) | 846.84 mi (1,362.85 km) |
| McDonough to On Top of the World Designated Place (Florida) | 319.01 mi (513.40 km) |
| McDonough to Onalaska (Wisconsin) | 815.40 mi (1,312.27 km) |
| McDonough to Oneida (New York) | 808.63 mi (1,301.36 km) |
| McDonough to Oneonta (New York) | 794.58 mi (1,278.75 km) |
| McDonough to Ontario (California) | 1,914.06 mi (3,080.37 km) |
| McDonough to Ontario (Oregon) | 1,898.66 mi (3,055.60 km) |
| McDonough to Opa-locka (Florida) | 570.90 mi (918.78 km) |
| McDonough to Opelika (Alabama) | 89.09 mi (143.38 km) |
| McDonough to Opelousas (Louisiana) | 506.36 mi (814.90 km) |
| McDonough to Orange (California) | 1,928.68 mi (3,103.91 km) |
| McDonough to Orange (Texas) | 608.87 mi (979.89 km) |
| McDonough to Orange City (Florida) | 354.22 mi (570.07 km) |
| McDonough to Orangeburg (South Carolina) | 189.28 mi (304.61 km) |
