| McDonough to Enterprise (Nevada) | 1,766.24 mi (2,842.49 km) |
| McDonough to Enumclaw (Washington) | 2,180.66 mi (3,509.44 km) |
| McDonough to Ephrata (Pennsylvania) | 640.77 mi (1,031.22 km) |
| McDonough to Erie (Colorado) | 1,239.54 mi (1,994.84 km) |
| McDonough to Erie (Pennsylvania) | 639.32 mi (1,028.89 km) |
| McDonough to Erlanger (Kentucky) | 385.70 mi (620.72 km) |
| McDonough to Escanaba (Michigan) | 864.51 mi (1,391.30 km) |
| McDonough to Escondido (California) | 1,893.53 mi (3,047.34 km) |
| McDonough to Española (New Mexico) | 1,254.56 mi (2,019.01 km) |
| McDonough to Essex (Maryland) | 589.34 mi (948.45 km) |
| McDonough to Essex Junction (Vermont) | 964.79 mi (1,552.68 km) |
| McDonough to Estelle (Louisiana) | 429.12 mi (690.60 km) |
| McDonough to Estero (Florida) | 504.55 mi (811.99 km) |
| McDonough to Euclid (Ohio) | 581.24 mi (935.42 km) |
| McDonough to Eufaula (Alabama) | 120.62 mi (194.12 km) |
