| Manhattan to University Place (Washington) | 2,414.84 mi (3,886.31 km) |
| Manhattan to Upland (California) | 2,415.01 mi (3,886.59 km) |
| Manhattan to Upper Arlington (Ohio) | 481.62 mi (775.09 km) |
| Manhattan to Upper Grand Lagoon (Florida) | 986.45 mi (1,587.53 km) |
| Manhattan to Upper Montclair (New Jersey) | 12.94 mi (20.82 km) |
| Manhattan to Urbana (Illinois) | 748.89 mi (1,205.23 km) |
| Manhattan to Urbana (Maryland) | 204.92 mi (329.78 km) |
| Manhattan to Urbana (Ohio) | 516.50 mi (831.22 km) |
| Manhattan to Urbandale (Iowa) | 1,029.37 mi (1,656.61 km) |
| Manhattan to Utica (New York) | 172.41 mi (277.47 km) |
| Manhattan to Uvalde (Texas) | 1,656.24 mi (2,665.46 km) |
| Manhattan to Vacaville (California) | 2,529.95 mi (4,071.57 km) |
| Manhattan to Vadnais Heights (Minnesota) | 1,008.16 mi (1,622.47 km) |
| Manhattan to Vail (Arizona) | 2,113.10 mi (3,400.70 km) |
| Manhattan to Valdosta (Georgia) | 860.99 mi (1,385.63 km) |
