| Manhattan to Southern Pines (North Carolina) | 486.49 mi (782.93 km) |
| Manhattan to Southfield (Michigan) | 493.76 mi (794.63 km) |
| Manhattan to Southgate (Michigan) | 487.88 mi (785.17 km) |
| Manhattan to Southlake (Texas) | 1,385.59 mi (2,229.88 km) |
| Manhattan to Spanaway (Washington) | 2,410.20 mi (3,878.84 km) |
| Manhattan to Spanish Fork (Utah) | 1,966.09 mi (3,164.11 km) |
| Manhattan to Spanish Lake (Missouri) | 871.97 mi (1,403.30 km) |
| Manhattan to Spanish Springs (Nevada) | 2,384.76 mi (3,837.90 km) |
| Manhattan to Sparks (Nevada) | 2,388.82 mi (3,844.44 km) |
| Manhattan to Spartanburg (South Carolina) | 592.18 mi (953.01 km) |
| Manhattan to Spearfish (South Dakota) | 1,529.89 mi (2,462.12 km) |
| Manhattan to Speedway (Indiana) | 650.37 mi (1,046.67 km) |
| Manhattan to Spencer (Iowa) | 1,097.64 mi (1,766.48 km) |
| Manhattan to Spokane (Washington) | 2,174.02 mi (3,498.75 km) |
| Manhattan to Spokane Valley (Washington) | 2,164.83 mi (3,483.96 km) |
