| Manhattan to Scottsboro (Alabama) | 783.80 mi (1,261.41 km) |
| Manhattan to Scottsdale (Arizona) | 2,124.18 mi (3,418.54 km) |
| Manhattan to Scranton (Pennsylvania) | 98.31 mi (158.21 km) |
| Manhattan to Seabrook (Maryland) | 197.22 mi (317.40 km) |
| Manhattan to Seabrook (Texas) | 1,413.25 mi (2,274.41 km) |
| Manhattan to Seaford (New York) | 26.07 mi (41.96 km) |
| Manhattan to Seagoville (Texas) | 1,365.69 mi (2,197.87 km) |
| Manhattan to Seal Beach (California) | 2,446.83 mi (3,937.79 km) |
| Manhattan to Searcy (Arkansas) | 1,037.94 mi (1,670.40 km) |
| Manhattan to Seaside (California) | 2,564.27 mi (4,126.80 km) |
| Manhattan to SeaTac (Washington) | 2,401.30 mi (3,864.52 km) |
| Manhattan to Seattle (Washington) | 2,401.00 mi (3,864.04 km) |
| Manhattan to Sebastian (Florida) | 971.51 mi (1,563.49 km) |
| Manhattan to Sebring (Florida) | 1,013.20 mi (1,630.58 km) |
| Manhattan to Secaucus (New Jersey) | 5.22 mi (8.40 km) |
