| Manhattan to Sanford (Maine) | 245.63 mi (395.31 km) |
| Manhattan to Sanford (North Carolina) | 462.49 mi (744.31 km) |
| Manhattan to Sanger (California) | 2,445.47 mi (3,935.60 km) |
| Manhattan to Santa Ana (California) | 2,437.43 mi (3,922.67 km) |
| Manhattan to Santa Barbara (California) | 2,513.76 mi (4,045.51 km) |
| Manhattan to Santa Clara (California) | 2,553.47 mi (4,109.42 km) |
| Manhattan to Santa Clara (Oregon) | 2,479.83 mi (3,990.90 km) |
| Manhattan to Santa Clarita (California) | 2,450.26 mi (3,943.31 km) |
| Manhattan to Santa Cruz (California) | 2,566.39 mi (4,130.20 km) |
| Manhattan to Santa Fe (New Mexico) | 1,763.22 mi (2,837.64 km) |
| Manhattan to Santa Fe (Texas) | 1,424.94 mi (2,293.22 km) |
| Manhattan to Santa Fe Springs (California) | 2,441.25 mi (3,928.82 km) |
| Manhattan to Santa Maria (California) | 2,537.43 mi (4,083.60 km) |
| Manhattan to Santa Monica (California) | 2,460.53 mi (3,959.84 km) |
| Manhattan to Santa Paula (California) | 2,481.70 mi (3,993.92 km) |
