| Manhattan to Olympia Heights (Florida) | 1,102.90 mi (1,774.94 km) |
| Manhattan to Omaha (Nebraska) | 1,148.69 mi (1,848.64 km) |
| Manhattan to On Top of the World Designated Place (Florida) | 933.29 mi (1,501.99 km) |
| Manhattan to Onalaska (Wisconsin) | 904.51 mi (1,455.67 km) |
| Manhattan to Oneida (New York) | 180.85 mi (291.05 km) |
| Manhattan to Oneonta (New York) | 128.73 mi (207.17 km) |
| Manhattan to Ontario (California) | 2,414.41 mi (3,885.62 km) |
| Manhattan to Ontario (Oregon) | 2,180.72 mi (3,509.52 km) |
| Manhattan to Opa-locka (Florida) | 1,089.75 mi (1,753.78 km) |
| Manhattan to Opelika (Alabama) | 843.81 mi (1,357.99 km) |
| Manhattan to Opelousas (Louisiana) | 1,235.60 mi (1,988.51 km) |
| Manhattan to Orange (California) | 2,432.37 mi (3,914.52 km) |
| Manhattan to Orange (Texas) | 1,330.61 mi (2,141.41 km) |
| Manhattan to Orange City (Florida) | 917.03 mi (1,475.81 km) |
| Manhattan to Orangeburg (South Carolina) | 630.58 mi (1,014.82 km) |
