| Manhattan to Enterprise (Nevada) | 2,237.73 mi (3,601.27 km) |
| Manhattan to Enumclaw (Washington) | 2,389.06 mi (3,844.82 km) |
| Manhattan to Ephrata (Pennsylvania) | 123.62 mi (198.94 km) |
| Manhattan to Erie (Colorado) | 1,626.94 mi (2,618.31 km) |
| Manhattan to Erie (Pennsylvania) | 329.33 mi (530.01 km) |
| Manhattan to Erlanger (Kentucky) | 575.73 mi (926.55 km) |
| Manhattan to Escanaba (Michigan) | 742.79 mi (1,195.41 km) |
| Manhattan to Escondido (California) | 2,412.65 mi (3,882.79 km) |
| Manhattan to Española (New Mexico) | 1,759.30 mi (2,831.32 km) |
| Manhattan to Essex (Maryland) | 166.32 mi (267.66 km) |
| Manhattan to Essex Junction (Vermont) | 259.75 mi (418.02 km) |
| Manhattan to Estelle (Louisiana) | 1,179.28 mi (1,897.86 km) |
| Manhattan to Estero (Florida) | 1,088.23 mi (1,751.33 km) |
| Manhattan to Euclid (Ohio) | 396.52 mi (638.14 km) |
| Manhattan to Eufaula (Alabama) | 872.24 mi (1,403.73 km) |
