| Manhattan to Elyria (Ohio) | 425.75 mi (685.18 km) |
| Manhattan to Emeryville (California) | 2,558.78 mi (4,117.95 km) |
| Manhattan to Emmaus (Pennsylvania) | 82.09 mi (132.11 km) |
| Manhattan to Emporia (Kansas) | 1,191.53 mi (1,917.58 km) |
| Manhattan to Encinitas (California) | 2,425.06 mi (3,902.75 km) |
| Manhattan to Endicott (New York) | 141.61 mi (227.90 km) |
| Manhattan to Endwell (New York) | 140.85 mi (226.68 km) |
| Manhattan to Englewood (Colorado) | 1,630.42 mi (2,623.91 km) |
| Manhattan to Englewood (Florida) | 1,067.39 mi (1,717.80 km) |
| Manhattan to Englewood (New Jersey) | 7.49 mi (12.06 km) |
| Manhattan to Englewood (Ohio) | 548.08 mi (882.05 km) |
| Manhattan to Enid (Oklahoma) | 1,321.33 mi (2,126.47 km) |
| Manhattan to Ennis (Texas) | 1,381.82 mi (2,223.83 km) |
| Manhattan to Ensley (Florida) | 1,027.50 mi (1,653.61 km) |
| Manhattan to Enterprise (Alabama) | 929.56 mi (1,495.98 km) |
