| Manchester to Southern Pines (North Carolina) | 3,811.35 mi (6,133.78 km) |
| Manchester to Southfield (Michigan) | 3,615.02 mi (5,817.82 km) |
| Manchester to Southgate (Michigan) | 3,625.54 mi (5,834.74 km) |
| Manchester to Southlake (Texas) | 4,613.19 mi (7,424.21 km) |
| Manchester to Spanaway (Washington) | 4,653.72 mi (7,489.44 km) |
| Manchester to Spanish Fork (Utah) | 4,732.44 mi (7,616.12 km) |
| Manchester to Spanish Lake (Missouri) | 4,053.86 mi (6,524.06 km) |
| Manchester to Spanish Springs (Nevada) | 5,004.49 mi (8,053.95 km) |
| Manchester to Sparks (Nevada) | 5,010.65 mi (8,063.86 km) |
| Manchester to Spartanburg (South Carolina) | 3,923.84 mi (6,314.82 km) |
| Manchester to Spearfish (South Dakota) | 4,245.26 mi (6,832.08 km) |
| Manchester to Speedway (Indiana) | 3,855.20 mi (6,204.35 km) |
| Manchester to Spencer (Iowa) | 4,018.42 mi (6,467.02 km) |
| Manchester to Spokane (Washington) | 4,487.10 mi (7,221.28 km) |
| Manchester to Spokane Valley (Washington) | 4,481.85 mi (7,212.84 km) |
