| Mack to Superior (Colorado) | 1,090.14 mi (1,754.41 km) |
| Mack to Superior (Wisconsin) | 641.27 mi (1,032.03 km) |
| Mack to Surprise (Arizona) | 1,582.96 mi (2,547.53 km) |
| Mack to Susanville (California) | 1,896.74 mi (3,052.50 km) |
| Mack to Sussex (Wisconsin) | 331.31 mi (533.19 km) |
| Mack to Suwanee (Georgia) | 353.89 mi (569.53 km) |
| Mack to Swansea (Illinois) | 288.47 mi (464.25 km) |
| Mack to Sweetwater (Florida) | 956.95 mi (1,540.06 km) |
| Mack to Sweetwater (Texas) | 992.94 mi (1,597.98 km) |
| Mack to Sycamore (Illinois) | 287.70 mi (463.01 km) |
| Mack to Sylacauga (Alabama) | 421.87 mi (678.93 km) |
| Mack to Sylvania (Ohio) | 184.14 mi (296.35 km) |
| Mack to Syosset (New York) | 602.41 mi (969.48 km) |
| Mack to Syracuse (New York) | 519.06 mi (835.35 km) |
| Mack to Syracuse (Utah) | 1,447.43 mi (2,329.41 km) |
