| Lyons to Superior (Colorado) | 913.57 mi (1,470.24 km) |
| Lyons to Superior (Wisconsin) | 397.73 mi (640.09 km) |
| Lyons to Surprise (Arizona) | 1,451.75 mi (2,336.36 km) |
| Lyons to Susanville (California) | 1,699.38 mi (2,734.88 km) |
| Lyons to Sussex (Wisconsin) | 93.67 mi (150.75 km) |
| Lyons to Suwanee (Georgia) | 573.71 mi (923.30 km) |
| Lyons to Swansea (Illinois) | 252.67 mi (406.63 km) |
| Lyons to Sweetwater (Florida) | 1,186.16 mi (1,908.95 km) |
| Lyons to Sweetwater (Texas) | 945.48 mi (1,521.61 km) |
| Lyons to Sycamore (Illinois) | 46.16 mi (74.29 km) |
| Lyons to Sylacauga (Alabama) | 602.60 mi (969.79 km) |
| Lyons to Sylvania (Ohio) | 211.92 mi (341.05 km) |
| Lyons to Syosset (New York) | 745.31 mi (1,199.47 km) |
| Lyons to Syracuse (New York) | 600.97 mi (967.17 km) |
| Lyons to Syracuse (Utah) | 1,252.74 mi (2,016.09 km) |
