| Lyons to Southern Pines (North Carolina) | 644.51 mi (1,037.24 km) |
| Lyons to Southfield (Michigan) | 237.98 mi (382.99 km) |
| Lyons to Southgate (Michigan) | 238.37 mi (383.62 km) |
| Lyons to Southlake (Texas) | 797.07 mi (1,282.76 km) |
| Lyons to Spanaway (Washington) | 1,730.33 mi (2,784.69 km) |
| Lyons to Spanish Fork (Utah) | 1,244.45 mi (2,002.74 km) |
| Lyons to Spanish Lake (Missouri) | 243.87 mi (392.47 km) |
| Lyons to Spanish Springs (Nevada) | 1,664.59 mi (2,678.89 km) |
| Lyons to Sparks (Nevada) | 1,668.53 mi (2,685.23 km) |
| Lyons to Spartanburg (South Carolina) | 571.57 mi (919.85 km) |
| Lyons to Spearfish (South Dakota) | 825.84 mi (1,329.07 km) |
| Lyons to Speedway (Indiana) | 161.84 mi (260.46 km) |
| Lyons to Spencer (Iowa) | 384.81 mi (619.29 km) |
| Lyons to Spokane (Washington) | 1,498.42 mi (2,411.47 km) |
| Lyons to Spokane Valley (Washington) | 1,489.19 mi (2,396.62 km) |
