| Lyons to Silver Firs (Washington) | 1,717.85 mi (2,764.61 km) |
| Lyons to Silver Spring (Maryland) | 599.85 mi (965.37 km) |
| Lyons to Silver Springs Shores (Florida) | 935.66 mi (1,505.79 km) |
| Lyons to Silverdale (Washington) | 1,742.40 mi (2,804.13 km) |
| Lyons to Silverton (Oregon) | 1,754.89 mi (2,824.23 km) |
| Lyons to Simi Valley (California) | 1,751.16 mi (2,818.22 km) |
| Lyons to Simpsonville (South Carolina) | 574.62 mi (924.76 km) |
| Lyons to Sioux City (Iowa) | 441.37 mi (710.31 km) |
| Lyons to Sioux Falls (South Dakota) | 467.92 mi (753.04 km) |
| Lyons to Skokie (Illinois) | 16.01 mi (25.76 km) |
| Lyons to Sleepy Hollow (New York) | 723.15 mi (1,163.80 km) |
| Lyons to Slidell (Louisiana) | 803.63 mi (1,293.32 km) |
| Lyons to Smithfield (North Carolina) | 670.37 mi (1,078.86 km) |
| Lyons to Smithfield (Utah) | 1,232.05 mi (1,982.80 km) |
| Lyons to Smithville (Missouri) | 391.70 mi (630.38 km) |
