| Lyons to Seymour (Tennessee) | 464.21 mi (747.08 km) |
| Lyons to Shady Hills (Florida) | 972.61 mi (1,565.26 km) |
| Lyons to Shafter (California) | 1,738.52 mi (2,797.88 km) |
| Lyons to Shaker Heights (Ohio) | 324.48 mi (522.20 km) |
| Lyons to Shakopee (Minnesota) | 350.38 mi (563.89 km) |
| Lyons to Sharon (Pennsylvania) | 380.61 mi (612.52 km) |
| Lyons to Sharonville (Ohio) | 250.22 mi (402.70 km) |
| Lyons to Shasta Lake (California) | 1,784.90 mi (2,872.52 km) |
| Lyons to Shawnee (Kansas) | 415.12 mi (668.07 km) |
| Lyons to Shawnee (Oklahoma) | 664.98 mi (1,070.18 km) |
| Lyons to Sheboygan (Wisconsin) | 133.31 mi (214.55 km) |
| Lyons to Shelby (North Carolina) | 563.52 mi (906.90 km) |
| Lyons to Shelbyville (Indiana) | 190.17 mi (306.05 km) |
| Lyons to Shelbyville (Kentucky) | 284.28 mi (457.50 km) |
| Lyons to Shelbyville (Tennessee) | 442.38 mi (711.94 km) |
