| Lyons to Santa Rosa (California) | 1,844.88 mi (2,969.05 km) |
| Lyons to Santaquin (Utah) | 1,254.58 mi (2,019.06 km) |
| Lyons to Santee (California) | 1,707.42 mi (2,747.82 km) |
| Lyons to Sapulpa (Oklahoma) | 598.61 mi (963.37 km) |
| Lyons to Saraland (Alabama) | 757.70 mi (1,219.40 km) |
| Lyons to Sarasota (Florida) | 1,043.51 mi (1,679.36 km) |
| Lyons to Sarasota Springs (Florida) | 1,046.62 mi (1,684.37 km) |
| Lyons to Saratoga (California) | 1,837.04 mi (2,956.43 km) |
| Lyons to Saratoga Springs (New York) | 720.36 mi (1,159.30 km) |
| Lyons to Saratoga Springs (Utah) | 1,254.97 mi (2,019.68 km) |
| Lyons to Sartell (Minnesota) | 413.76 mi (665.88 km) |
| Lyons to Satellite Beach (Florida) | 1,025.77 mi (1,650.82 km) |
| Lyons to Sauk Rapids (Minnesota) | 410.32 mi (660.35 km) |
| Lyons to Sault Ste. Marie (Michigan) | 365.02 mi (587.44 km) |
| Lyons to Savage (Minnesota) | 344.97 mi (555.18 km) |
