| Lyons to Olympia Heights (Florida) | 1,190.48 mi (1,915.89 km) |
| Lyons to Omaha (Nebraska) | 427.36 mi (687.76 km) |
| Lyons to On Top of the World Designated Place (Florida) | 930.93 mi (1,498.19 km) |
| Lyons to Onalaska (Wisconsin) | 223.67 mi (359.96 km) |
| Lyons to Oneida (New York) | 625.40 mi (1,006.48 km) |
| Lyons to Oneonta (New York) | 654.31 mi (1,053.01 km) |
| Lyons to Ontario (California) | 1,699.95 mi (2,735.81 km) |
| Lyons to Ontario (Oregon) | 1,475.44 mi (2,374.48 km) |
| Lyons to Opa-locka (Florida) | 1,180.74 mi (1,900.22 km) |
| Lyons to Opelika (Alabama) | 646.28 mi (1,040.10 km) |
| Lyons to Opelousas (Louisiana) | 814.97 mi (1,311.58 km) |
| Lyons to Orange (California) | 1,718.41 mi (2,765.51 km) |
| Lyons to Orange (Texas) | 872.74 mi (1,404.54 km) |
| Lyons to Orange City (Florida) | 962.03 mi (1,548.24 km) |
| Lyons to Orangeburg (South Carolina) | 688.65 mi (1,108.28 km) |
