| Lyons to Enterprise (Nevada) | 1,519.93 mi (2,446.10 km) |
| Lyons to Enumclaw (Washington) | 1,709.91 mi (2,751.84 km) |
| Lyons to Ephrata (Pennsylvania) | 616.76 mi (992.58 km) |
| Lyons to Erie (Colorado) | 905.72 mi (1,457.62 km) |
| Lyons to Erie (Pennsylvania) | 398.36 mi (641.10 km) |
| Lyons to Erlanger (Kentucky) | 257.60 mi (414.56 km) |
| Lyons to Escanaba (Michigan) | 274.36 mi (441.53 km) |
| Lyons to Escondido (California) | 1,702.34 mi (2,739.66 km) |
| Lyons to Española (New Mexico) | 1,057.39 mi (1,701.71 km) |
| Lyons to Essex (Maryland) | 621.21 mi (999.74 km) |
| Lyons to Essex Junction (Vermont) | 762.82 mi (1,227.65 km) |
| Lyons to Estelle (Louisiana) | 836.59 mi (1,346.37 km) |
| Lyons to Estero (Florida) | 1,116.63 mi (1,797.04 km) |
| Lyons to Euclid (Ohio) | 325.30 mi (523.52 km) |
| Lyons to Eufaula (Alabama) | 699.76 mi (1,126.16 km) |
